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    Gentamicin

    Kathryn Dzintars, Pharm.D., BCPS, Paul A. Pham, Pharm.D.
    Gentamicin is a topic covered in the Johns Hopkins ABX Guide.

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    INDICATIONS

    FDA

    1. Serious infections caused by susceptible strains of organism.
      1. With the exception of uncomplicated UTI, aminoglycosides are generally used in combination for serious infections.
    2. Bacterial septicemia, including neonatal sepsis
    3. Skin, bone and soft tissue infections (including burns)
    4. Meningitis (poor penetration)
    5. Urinary tract
    6. Respiratory tract (poor penetration)
    7. Gastrointestinal tract (including peritonitis)
    8. Inflammatory ocular conditions that are steroid-responsive (opthalmic ointment and suspension)

    NON-FDA APPROVED USES

    1. Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
    2. Intra-abdominal infection (in combination with an agent with Gram-positive and anaerobe coverage)
    3. Enterococcal endocarditis (in combination with ampicillin)
    4. Pelvic inflammatory disease (PID, in combination with clindamycin)
    5. Infections caused by P. aeruginosa (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third/fourth-generation cephalosporin)
    6. Brucella Species

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    Last updated: April 5, 2017

    Citation

    Dzintars, Kathryn, and Paul A Pham. "Gentamicin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540245/all/Gentamicin.
    Dzintars K, Pham PA. Gentamicin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540245/all/Gentamicin. Accessed April 18, 2019.
    Dzintars, K., & Pham, P. A. (2017). Gentamicin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540245/all/Gentamicin
    Dzintars K, Pham PA. Gentamicin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 April 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540245/all/Gentamicin.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Gentamicin ID - 540245 A1 - Dzintars,Kathryn,Pharm.D., BCPS AU - Pham,Paul,Pharm.D. Y1 - 2017/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540245/all/Gentamicin PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -