Johns Hopkins ABX Guide
Gas Gangrene
Gas Gangrene is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
Common clostridial species causing gas gangrene:
- Clostridium perfringens
- Most commonly identified organism.
- Produces > 20 exotoxins, including lethal Alpha and Beta toxins that cause necrosis and hemolysis.
- Clostridium novyi
- Clostridium septicum
- Clostridium histolyticum
- Clostridium sordellii (seen with toxic shock after childbirth, users of contaminated heroin injections and patients with malignancy)
- Review of spontaneous C. sordelli-associated gas gangrene found that known or occult malignancy was seen in 71% of the 94 patients in the literature; overall mortality was 67%[3].
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PATHOGENS
Common clostridial species causing gas gangrene:
- Clostridium perfringens
- Most commonly identified organism.
- Produces > 20 exotoxins, including lethal Alpha and Beta toxins that cause necrosis and hemolysis.
- Clostridium novyi
- Clostridium septicum
- Clostridium histolyticum
- Clostridium sordellii (seen with toxic shock after childbirth, users of contaminated heroin injections and patients with malignancy)
- Review of spontaneous C. sordelli-associated gas gangrene found that known or occult malignancy was seen in 71% of the 94 patients in the literature; overall mortality was 67%[3].
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Last updated: August 9, 2019
Citation
Auwaerter, Paul G. "Gas Gangrene." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene.
Auwaerter PG. Gas Gangrene. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene. Accessed March 22, 2023.
Auwaerter, P. G. (2019). Gas Gangrene. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene
Auwaerter PG. Gas Gangrene [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2023 March 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene.
* Article titles in AMA citation format should be in sentence-case
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T1 - Gas Gangrene
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A1 - Auwaerter,Paul,M.D.
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PB - The Johns Hopkins University
DB - Pediatrics Central
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