Francisella tularensis
Francisella tularensis is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Small, pleomorphic, intracellular and extracellular fastidious aerobic Gram-negative coccobacillus [Fig 1].
- Culture: poor or no growth on standard media.
- Media most often employed: Thayer-Martin, BCYE or chocolate agar with addition of cysteine and/or cysteine (thioglycolate).
- MacConkey does not yield growth.
- Slow grower, may require CO2 supplementation.
- Media most often employed: Thayer-Martin, BCYE or chocolate agar with addition of cysteine and/or cysteine (thioglycolate).
- Considered an important laboratory hazard to laboratory personnel requiring specialized safety procedures. Notify lab if considering diagnosis when submitting specimens; higher level labs may be required.
- Four recognized subspecies that vary in location and virulence:
- F. tularensis: distinguished by PCR.
- Biovar tularensis (Type A), typically associated with lagomorphs (hares, rabbits, pikas)
- Biovar holarctica (B), frequently associated with rodents and aquatic environments
- Biovar mediasiatica and subspecies novicida
- F. tularensis: distinguished by PCR.
-- To view the remaining sections of this topic, please log in or purchase a subscription --
MICROBIOLOGY
- Small, pleomorphic, intracellular and extracellular fastidious aerobic Gram-negative coccobacillus [Fig 1].
- Culture: poor or no growth on standard media.
- Media most often employed: Thayer-Martin, BCYE or chocolate agar with addition of cysteine and/or cysteine (thioglycolate).
- MacConkey does not yield growth.
- Slow grower, may require CO2 supplementation.
- Media most often employed: Thayer-Martin, BCYE or chocolate agar with addition of cysteine and/or cysteine (thioglycolate).
- Considered an important laboratory hazard to laboratory personnel requiring specialized safety procedures. Notify lab if considering diagnosis when submitting specimens; higher level labs may be required.
- Four recognized subspecies that vary in location and virulence:
- F. tularensis: distinguished by PCR.
- Biovar tularensis (Type A), typically associated with lagomorphs (hares, rabbits, pikas)
- Biovar holarctica (B), frequently associated with rodents and aquatic environments
- Biovar mediasiatica and subspecies novicida
- F. tularensis: distinguished by PCR.
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Last updated: February 5, 2019
Citation
Fabre, Valeria Fabre. "Francisella Tularensis." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis.
Fabre V. Francisella tularensis. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis. Accessed January 27, 2023.
Fabre, V. (2019). Francisella tularensis. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis
Fabre V. Francisella Tularensis [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2023 January 27]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis.
* Article titles in AMA citation format should be in sentence-case
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T1 - Francisella tularensis
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A1 - Fabre,Valeria Fabre,M.D.
Y1 - 2019/02/05/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
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