Johns Hopkins ABX Guide
Fever and Neutropenia
DEFINITION
- Febrile neutropenia[8]
- Fever: single oral temp ≥38.3°C (101°F) or temp ≥38°C (100.4°F) sustained for 1h AND
- Neutropenia: absolute neutrophil count (ANC) ≤500 cells/mm3 OR ANC predicted to decrease to ≤500 cells/mm3 in 48h
- Neutrophils create host responses, especially to bacterial and fungal infections. The depth and duration of neutropenia determine the degree of immunocompromise.[2]
- Caveat: Course may be fulminant, and signs and symptoms typical of bacterial infection (i.e., induration, erythema, pustulation, CXR infiltrates, CSF pleocytosis) may be absent.
- The mortality rate is as high as 50% in those presenting to the hospital with severe sepsis or shock.
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Last updated: January 13, 2023
Citation
Spacek, Lisa A. "Fever and Neutropenia." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia.
Spacek LA. Fever and Neutropenia. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia. Accessed December 4, 2024.
Spacek, L. A. (2023). Fever and Neutropenia. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia
Spacek LA. Fever and Neutropenia [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2024 December 04]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia.
* Article titles in AMA citation format should be in sentence-case
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T1 - Fever and Neutropenia
ID - 540221
A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2023/01/13/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540221/all/Fever_and_Neutropenia
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
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