FDA

Dapsone Tablets

• Leprosy, as part of an appropriate combination regimen
  • Both paucibacillary and multibacillary: all forms except proven dapsone resistance; use as part of multidrug therapy.
• Dermatitis herpetiformis

Dapsone Gel

• Acne vulargis
  • 5% gel: ≥12 years
  • 7.5% gel: ≥9 years

NON-FDA APPROVED USES

• Dapsone is used off-label for numerous inflammatory dermatoses, with variable evidence, including selected autoimmune/bullous disorders (e.g., linear IgA bullous dermatosis, bullous pemphigoid, pemphigus), neutrophilic dermatoses (e.g., Sweet syndrome, pyoderma gangrenosum, subcorneal pustular dermatosis), vasculitic disorders, and selected eosinophilic/inflammatory dermatoses.[4]
• Aphthous ulcers, severe
• PJP
  • Prophylaxis as monotherapy or part of a combination therapy
  • Treatment of mild-to-moderate disease as part of a combination therapy
• Toxoplasma gondii encephalitis prophylaxis as combination therapy