- A ubiquitous, large, enveloped dsDNA beta-herpesvirus that establishes lifelong latency after primary infection and exhibits significant genotypic diversity.
- Cultured from urine, blood, throat, tears, stool, cervix, semen, and breast milk.
- Exhibits slow growth in cell culture.
- Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
- Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.
- Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.
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Last updated: March 5, 2022
Spacek, Lisa A. "Cytomegalovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
Spacek LA. Cytomegalovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus. Accessed November 30, 2023.
Spacek, L. A. (2022). Cytomegalovirus. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus
Spacek LA. Cytomegalovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2023 November 30]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
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