Cytomegalovirus

Lisa A. Spacek, M.D., Ph.D.
Cytomegalovirus is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Ubiquitous, large, enveloped dsDNA beta-herpesvirus; establishes lifelong latency after primary infection and exhibits significant genotypic diversity.[3]
  • Cultured from urine, blood, throat, tears, stool, cervix, semen, breast milk.
  • Exhibits slow growth in cell culture.
    • Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
  • Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.[11]
  • Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.[1]

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MICROBIOLOGY

  • Ubiquitous, large, enveloped dsDNA beta-herpesvirus; establishes lifelong latency after primary infection and exhibits significant genotypic diversity.[3]
  • Cultured from urine, blood, throat, tears, stool, cervix, semen, breast milk.
  • Exhibits slow growth in cell culture.
    • Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
  • Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.[11]
  • Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.[1]

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Last updated: December 6, 2020