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    Cytomegalovirus

    Lisa A. Spacek, M.D., Ph.D.
    Cytomegalovirus is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Ubiquitous, large, enveloped dsDNA betaherpesvirus; establishes lifelong latency after primary infection.
    • Transmitted sexually or by close contact, blood or tissue exposure, perinatally. Cultured from urine, blood, throat, tears, stool, cervix, semen, breast milk.
    • Seroprevalence increases with age. Adult seroprevalence rates range from 40-100% and are highest in developing countries.
    • Exhibits slow growth in cultured cells (can be up to 6 weeks until cytopathic effect is detected in tissue culture) and cytopathology is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
    • Isolation of virus or detection of viral proteins or nucleic acid defines CMV infection. Presence of signs/symptoms of end organ disease + CMV infection = CMV disease.

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    Last updated: June 25, 2012

    Citation

    Spacek, Lisa A. "Cytomegalovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2012. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
    Spacek LA. Cytomegalovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2012. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus. Accessed April 22, 2019.
    Spacek, L. A. (2012). Cytomegalovirus. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus
    Spacek LA. Cytomegalovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2012. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Cytomegalovirus ID - 540153 A1 - Spacek,Lisa,M.D., Ph.D. Y1 - 2012/06/25/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -