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- Ubiquitous, large, enveloped dsDNA betaherpesvirus; establishes lifelong latency after primary infection.
- Transmitted sexually or by close contact, blood or tissue exposure, perinatally. Cultured from urine, blood, throat, tears, stool, cervix, semen, breast milk.
- Seroprevalence increases with age. Adult seroprevalence rates range from 40-100% and are highest in developing countries.
- Exhibits slow growth in cultured cells (can be up to 6 weeks until cytopathic effect is detected in tissue culture) and cytopathology is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
- Isolation of virus or detection of viral proteins or nucleic acid defines CMV infection. Presence of signs/symptoms of end organ disease + CMV infection = CMV disease.
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Last updated: June 25, 2012
Spacek, Lisa A. "Cytomegalovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2012. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
Spacek LA. Cytomegalovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2012. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus. Accessed April 22, 2019.
Spacek, L. A. (2012). Cytomegalovirus. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus
Spacek LA. Cytomegalovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2012. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
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T1 - Cytomegalovirus
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A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2012/06/25/
BT - Johns Hopkins ABX Guide
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PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine