Cryptococcal Meningitis

Cryptococcal Meningitis is a topic covered in the Johns Hopkins ABX Guide.

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PATHOGENS

  • Main human pathogen:
    • Cryptococcus neoformans (predominant)
      • Four serotypes (A to D) described based upon the capsule components.
      • Three varieties described as causing human disease C. neoformans v. neoformans (most common), v. gattii, and v. grubii (recently established).
    • C. gattii: unlike C. neoformans, is more commonly seen in healthy hosts.
      • Has reduced sensitivity to fluconazole and appears to be more virulent.

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Last updated: February 3, 2016