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Clostridioides (ex. Clostridium) difficile

Clostridioides (ex. Clostridium) difficile is a topic covered in the Johns Hopkins ABX Guide.

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  • Spore-forming anaerobe, Gram-positive bacillus [Fig 1].
    • Found in human and animal feces, also in water and soils.
    • Reclassified as molecular sequencing suggests that the organism should be in the Peptostreptococcaceae family and termed Peptoclostridium.
      • Clostridioides difficile name selected to differentiate from Clostridiaspp. which are not related but allowing for less clinical confusion moving from the long-standing terminology of Clostridium difficile[7].
  • Produces toxins A and B that cause colitis in humans.
  • Occasionally grown in anaerobic cultures, rarely a cause of infection other than colitis.

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Last updated: June 6, 2019


Bartlett, John G. "Clostridioides (ex. Clostridium) Difficile." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/all/Clostridioides__ex__Clostridium__difficile.
Bartlett JG. Clostridioides (ex. Clostridium) difficile. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/all/Clostridioides__ex__Clostridium__difficile. Accessed July 17, 2019.
Bartlett, J. G. (2019). Clostridioides (ex. Clostridium) difficile. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/all/Clostridioides__ex__Clostridium__difficile
Bartlett JG. Clostridioides (ex. Clostridium) Difficile [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 July 17]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/all/Clostridioides__ex__Clostridium__difficile.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Clostridioides (ex. Clostridium) difficile ID - 540134 A1 - Bartlett,John,M.D. Y1 - 2019/06/06/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/all/Clostridioides__ex__Clostridium__difficile PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -