Clostridioides (ex. Clostridium) difficile
Clostridioides (ex. Clostridium) difficile is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Spore-forming anaerobe, Gram-positive bacillus [Fig 1].
- Found in human and animal feces, also in water and soils.
- Reclassified as molecular sequencing suggests that the organism should be in the Peptostreptococcaceae family and termed Peptoclostridium.
- Clostridioides difficile name selected to differentiate from Clostridiaspp., which are not related but allowing for less clinical confusion moving from the long-standing terminology of Clostridium difficile[12].
- Produces toxins A and B that cause colitis in humans.
- Occasionally grown in anaerobic cultures, rarely a cause of infection other than colitis.
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MICROBIOLOGY
- Spore-forming anaerobe, Gram-positive bacillus [Fig 1].
- Found in human and animal feces, also in water and soils.
- Reclassified as molecular sequencing suggests that the organism should be in the Peptostreptococcaceae family and termed Peptoclostridium.
- Clostridioides difficile name selected to differentiate from Clostridiaspp., which are not related but allowing for less clinical confusion moving from the long-standing terminology of Clostridium difficile[12].
- Produces toxins A and B that cause colitis in humans.
- Occasionally grown in anaerobic cultures, rarely a cause of infection other than colitis.
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Last updated: September 14, 2021
Citation
Auwaerter, Paul G. "Clostridioides (ex. Clostridium) Difficile." Johns Hopkins ABX Guide, The Johns Hopkins University, 2021. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/8/Clostridioides__ex__Clostridium__difficile.
Auwaerter PG. Clostridioides (ex. Clostridium) difficile. Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/8/Clostridioides__ex__Clostridium__difficile. Accessed March 25, 2023.
Auwaerter, P. G. (2021). Clostridioides (ex. Clostridium) difficile. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/8/Clostridioides__ex__Clostridium__difficile
Auwaerter PG. Clostridioides (ex. Clostridium) Difficile [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. [cited 2023 March 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540134/8/Clostridioides__ex__Clostridium__difficile.
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T1 - Clostridioides (ex. Clostridium) difficile
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A1 - Auwaerter,Paul,M.D.
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