Chikungunya virus

Paul Auwaerter, M.D.
Chikungunya virus is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Chikungunya virus (CHKV): single positive-strand RNA arbovirus [Fig 1] of family Togaviridae, genus Alphavirus.
    • A name taken from the East African/Mozambique Makonde language, "that which bends up," is believed to describe contortions due to severe joint pain.
  • Human infection is vector-borne, primarily mosquitoes (e.g., Aedes albopictus, FIg 2)
    • Outbreaks (2005-2006) in Indian Ocean islands may represent a more virulent strain than historically, as complications (meningoencephalitis, multiorgan dysfunction) and death were reported more frequently.
  • Human disease, especially arthropathy, is similar to the alphavirus, Ross River virus infection.

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MICROBIOLOGY

  • Chikungunya virus (CHKV): single positive-strand RNA arbovirus [Fig 1] of family Togaviridae, genus Alphavirus.
    • A name taken from the East African/Mozambique Makonde language, "that which bends up," is believed to describe contortions due to severe joint pain.
  • Human infection is vector-borne, primarily mosquitoes (e.g., Aedes albopictus, FIg 2)
    • Outbreaks (2005-2006) in Indian Ocean islands may represent a more virulent strain than historically, as complications (meningoencephalitis, multiorgan dysfunction) and death were reported more frequently.
  • Human disease, especially arthropathy, is similar to the alphavirus, Ross River virus infection.

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Last updated: January 12, 2023