Johns Hopkins ABX Guide
Cefaclor
INDICATIONS
FDA
FDA
- Otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Staphylococci, and Streptococcus pyogenes
- Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus (author’s comment: not a first-line agent)
- Not listed for pneumonia by ATS/IDSA 2019 guideline.
- AECB: FDA-labeled only for cefaclor ER; dose 500 mg PO q12h x 7d
- Pharyngitis and tonsillitis caused by Streptococcus pyogenes (PCN is the drug of choice).
- Cefaclor is not a usual preferred alternative; CDC lists cephalexin or cefadroxil among oral cephalosporin options for non-immediate penicillin allergy.
- Pyelonephritis and cystitis caused by Escherichia coli, Proteus mirabilis, Klebsiella spp, and coagulase-negative staphylococci (author’s comment: not a first-line agent)
- Skin and skin structure infections caused by Staphylococcus aureus (MSSA) and Streptococcus pyogenes
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Last updated: August 2, 2026
Citation
Soto, Caitlin, and Edina Avdic. "Cefaclor." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540084/all/Cefaclor.
Soto C, Avdic E. Cefaclor. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540084/all/Cefaclor. Accessed August 6, 2026.
Soto, C., & Avdic, E. (2026). Cefaclor. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540084/all/Cefaclor
Soto C, Avdic E. Cefaclor [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 August 06]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540084/all/Cefaclor.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Cefaclor
ID - 540084
A1 - Soto,Caitlin,PharmD, BCIDP
AU - Avdic,Edina,Pharm.D.
Y1 - 2026/08/02/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540084/all/Cefaclor
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
