Burkholderia cepacia complex
MICROBIOLOGY
- Multi-species complex of bacteria, B. cepacia complex (Bcc) with species: B. cepacia, B. cenocepacia, B. multivorans, B. stablis, B. vietnamiensis, B. dolosa, B. ambifaria, B. lata, B. pyrrocinia.
- Known to produce secondary metabolites with antifungal and antimicrobial properties.[16]
- Non-fermenting, aerobic Gram-negative rod [Fig 1]. Originally described by Burkholder as a causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion).[17]
- Formerly known as Pseudomonas cepacia.
- A waterborne, nosocomial, opportunistic pathogen is ubiquitous in water, soil, and plants.
- Recognized as the etiologic agent of "foot rot" or "swamp rot," maceration and hyperkeratosis affecting the toe webs of American soldiers who trained in wet terrain.[11]
- Adheres to epithelial cells and mucin; survives inside epithelial cells and macrophages; forms biofilms; and secretes catalases, proteases and siderophores.[1]
- B. cenocepacia is associated with the highest risk of mortality.[18]
- B. cenocepacia ET-12 strain is associated with nosocomial transmission.[7]
- Inherently resistant to many antibiotics, including first- and second-generation cephalosporins, carboxypenicillins, aminoglycosides and polymyxins.[11] Multi-drug resistance is common.[22][14]
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Last updated: June 18, 2023
Citation
Spacek, Lisa. "Burkholderia Cepacia Complex." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex.
Spacek L. Burkholderia cepacia complex. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex. Accessed December 3, 2024.
Spacek, L. (2023). Burkholderia cepacia complex. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex
Spacek L. Burkholderia Cepacia Complex [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2024 December 03]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex.
* Article titles in AMA citation format should be in sentence-case
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T1 - Burkholderia cepacia complex
ID - 540069
A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2023/06/18/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
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