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Burkholderia cepacia complex

Lisa Spacek, M.D., Ph.D., John G. Bartlett, M.D.
Burkholderia cepacia complex is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Multi-species complex of bacteria, B. cepacia complex (Bcc) with species: B. cepacia, B. cenocepacia, B. multivorans, B. stablis, B. vietnamiensis, B. dolosa, B. ambifaria, B. lata, B. pyrrocinia.[6]
    • Known to produce secondary metabolites with antifungal and antimicrobial properties.[6]
    • Biosynthesis of antibiotics is controlled by quorum sensing, a global regulation system that coordinates bacteria behavior, allows cell-to-cell communication, and alters gene expression according to population density.[6][10]
  • Non-fermenting, aerobic Gram-negative rods. Originally described by Burkholder as causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion).[7]
    • Waterborne, nosocomial, opportunistic pathogen. Ubiquitous in water, soil, plants. Patient-to-patient epidemic spread associated with increased mortality.
    • Adheres to epithelial cells and mucin; survives inside epithelial cells and macrophages; forms biofilms; secretes catalases, proteases and siderophores.[1]
    • Formerly known as Pseudomonas cepacia.

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Last updated: June 9, 2017

Citation

Spacek, Lisa, and John G Bartlett. "Burkholderia Cepacia Complex." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex.
Spacek L, Bartlett JG. Burkholderia cepacia complex. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex. Accessed March 19, 2019.
Spacek, L., & Bartlett, J. G. (2017). Burkholderia cepacia complex. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex
Spacek L, Bartlett JG. Burkholderia Cepacia Complex [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 March 19]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Burkholderia cepacia complex ID - 540069 A1 - Spacek,Lisa,M.D., Ph.D. AU - Bartlett,John,M.D. Y1 - 2017/06/09/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -