Burkholderia cepacia complex
Burkholderia cepacia complex is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Multi-species complex of bacteria, B. cepacia complex (Bcc) with species: B. cepacia, B. cenocepacia, B. multivorans, B. stablis, B. vietnamiensis, B. dolosa, B. ambifaria, B. lata, B. pyrrocinia.
- Known to produce secondary metabolites with antifungal and antimicrobial properties.[10]
- Non-fermenting, aerobic Gram-negative rod [Fig 1]. Originally described by Burkholder as a causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion).[11]
- Formerly known as Pseudomonas cepacia.
- Waterborne, nosocomial, opportunistic pathogen. Ubiquitous in water, soil, plants.
- Recognized as the etiologic agent of "foot rot" or "swamp rot," maceration and hyperkeratosis affecting the toe webs of American soldiers who trained in wet terrain.[6]
- Adheres to epithelial cells and mucin; survives inside epithelial cells and macrophages; forms biofilms; secretes catalases, proteases and siderophores.[1]
- B. cenocepacia associated with the highest risk of mortality.[12]
- Inherently resistant to many antibiotics, including first and second-generation cephalosporins, carboxypenicillins, aminoglycosides and polymyxins.[6] Multi-drug resistance is common.[16][8]
-- To view the remaining sections of this topic, please log in or purchase a subscription --
MICROBIOLOGY
- Multi-species complex of bacteria, B. cepacia complex (Bcc) with species: B. cepacia, B. cenocepacia, B. multivorans, B. stablis, B. vietnamiensis, B. dolosa, B. ambifaria, B. lata, B. pyrrocinia.
- Known to produce secondary metabolites with antifungal and antimicrobial properties.[10]
- Non-fermenting, aerobic Gram-negative rod [Fig 1]. Originally described by Burkholder as a causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion).[11]
- Formerly known as Pseudomonas cepacia.
- Waterborne, nosocomial, opportunistic pathogen. Ubiquitous in water, soil, plants.
- Recognized as the etiologic agent of "foot rot" or "swamp rot," maceration and hyperkeratosis affecting the toe webs of American soldiers who trained in wet terrain.[6]
- Adheres to epithelial cells and mucin; survives inside epithelial cells and macrophages; forms biofilms; secretes catalases, proteases and siderophores.[1]
- B. cenocepacia associated with the highest risk of mortality.[12]
- Inherently resistant to many antibiotics, including first and second-generation cephalosporins, carboxypenicillins, aminoglycosides and polymyxins.[6] Multi-drug resistance is common.[16][8]
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Last updated: December 2, 2019
Citation
Spacek, Lisa. "Burkholderia Cepacia Complex." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/0/Burkholderia_cepacia_complex.
Spacek L. Burkholderia cepacia complex. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/0/Burkholderia_cepacia_complex. Accessed March 27, 2023.
Spacek, L. (2019). Burkholderia cepacia complex. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/0/Burkholderia_cepacia_complex
Spacek L. Burkholderia Cepacia Complex [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2023 March 27]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/0/Burkholderia_cepacia_complex.
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T1 - Burkholderia cepacia complex
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A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2019/12/02/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/0/Burkholderia_cepacia_complex
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -