Bacillus species
MICROBIOLOGY
- Facultative anaerobe or aerobic spore-forming is usually seen as a Gram-positive rod.
- See separate modules for anthrax (B. anthracis)
- Ubiquitous in decayed organic matter and soil. Some species are part of normal human flora.
- B. cereus produces toxins that have been linked to causing illness: the two below are among the better described that appear to bind to cell surface receptors LITAF and CDIP1 and cause potassium efflux, activating the NLRP3 inflammasome, leading to necrotic cell death.
- Hemolysin BL (HBL)
- Nonhemolytic enterotoxin (NHE)
- B. cereus produces toxins that have been linked to causing illness: the two below are among the better described that appear to bind to cell surface receptors LITAF and CDIP1 and cause potassium efflux, activating the NLRP3 inflammasome, leading to necrotic cell death.
- Potential human pathogens include B. cereus (most common), B. subtilis, B. megaterium, B. circulans, and B. sphaericus.
- B. cereus is typically susceptible to vancomycin, fluoroquinolones, carbapenems and gentamicin.
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Last updated: June 8, 2024
Citation
Auwaerter, Paul. "Bacillus Species." Johns Hopkins ABX Guide, The Johns Hopkins University, 2024. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540044/all/Bacillus_species.
Auwaerter P. Bacillus species. Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540044/all/Bacillus_species. Accessed December 10, 2024.
Auwaerter, P. (2024). Bacillus species. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540044/all/Bacillus_species
Auwaerter P. Bacillus Species [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. [cited 2024 December 10]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540044/all/Bacillus_species.
* Article titles in AMA citation format should be in sentence-case
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