Johns Hopkins ABX Guide
Anthrax
Anthrax is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Bacillus anthracis (Category A bioterrorism agent)
- Spore is a primary infectious form.
- Gram-positive, large rod-shaped organism [Fig 1]
- Virulence factors:
- Antiphagocytic capsule
- Exotoxins: why anti-toxin therapies have been developed given the prominence of these toxins in causing illness.
- Edema toxin (ET)
- Lethal toxin (LT)
- Protective antigen (PA) combines ET and LT and facilitates entry into cells and assists in downregulating immune responses.
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PATHOGENS
- Bacillus anthracis (Category A bioterrorism agent)
- Spore is a primary infectious form.
- Gram-positive, large rod-shaped organism [Fig 1]
- Virulence factors:
- Antiphagocytic capsule
- Exotoxins: why anti-toxin therapies have been developed given the prominence of these toxins in causing illness.
- Edema toxin (ET)
- Lethal toxin (LT)
- Protective antigen (PA) combines ET and LT and facilitates entry into cells and assists in downregulating immune responses.
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Last updated: February 10, 2020
Citation
Auwaerter, Paul G. "Anthrax." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540028/all/Anthrax.
Auwaerter PG. Anthrax. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540028/all/Anthrax. Accessed March 26, 2023.
Auwaerter, P. G. (2020). Anthrax. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540028/all/Anthrax
Auwaerter PG. Anthrax [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2023 March 26]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540028/all/Anthrax.
* Article titles in AMA citation format should be in sentence-case
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Y1 - 2020/02/10/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540028/all/Anthrax
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DB - Pediatrics Central
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