Amoxicillin
INDICATIONS
FDA
FDA
Treatment of infections due to susceptible (β-lactamase-negative) strains causing the following syndromes:
- Infections of the ear, nose, and throat – due to Streptococcus spp. (α- and β-hemolytic strains), S. pneumoniae, Staphylococcus spp., or H. influenzae
- Infections of the genitourinary tract – due to E. coli, P. mirabilis, or E. faecalis.
- Note: empiric use is not recommended by IDSA due to higher rates of resistance to E. coli and poor efficacy[3].
- Infections of the skin and skin structure – due to Streptococcus spp. (α- and β-hemolytic strains), Staphylococcus spp., or E. coli
- Infections of the lower respiratory tract – due to Streptococcus spp. (α- and β-hemolytic strains), S. pneumoniae, Staphylococcus spp., or H. influenzae
- Gonorrhea, acute uncomplicated (ano-genital and urethral infections) – due to N. gonorrhoeae (males and females). Note: amoxicillin is not recommended by the CDC for the treatment of gonorrhea due to high rates of resistance.
- H. pylori eradication to reduce the risk of duodenal ulcer recurrence in combination with other agents.
Amoxicillin ER tablet (Mmoxtag™) is indicated for the treatment of tonsillitis and/or pharyngitis secondary to Streptococcus pyogenes in adults and pediatric patients ≥12 y/o
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Lyme disease
- Non-severe Enterococcus infections
- Suppression therapy for prosthetic joint infections caused by streptococci, Enterococcus, C. acne
- Endocarditis prophylaxis
- Dental infections
- Low-risk penicillin allergies; challenge with oral penicillin "direct amoxicillin challenge"[16]
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Last updated: June 6, 2020
Citation
Avdic, Edina. "Amoxicillin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin.
Avdic E. Amoxicillin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin. Accessed December 3, 2024.
Avdic, E. (2020). Amoxicillin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin
Avdic E. Amoxicillin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2024 December 03]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540017/all/Amoxicillin.
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