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Trypanosoma brucei gambiense/rhodesiense

Trypanosoma brucei gambiense/rhodesiense is a topic covered in the Johns Hopkins ABX Guide.

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  • Protozoan hemoflagellate, agent of human African sleeping sickness.
  • Trypanosoma brucei complex of which two subspecies exist:
    • T. b. gambiense causes West African sleeping sickness
    • T. b. rhodesiense causes East African sleeping sickness
  • Trypanosomes, zoonotic infection of cattle and other animals, transmitted by the painful bite of TseTse fly (Fig 1, not preventable with DEET) usually in rural African locales.
    • Trypanosoma brucei gambiense (g-HAT): humans only known significant reservoir, hence efforts for eradication.
      • Other modes of transmission possible: but probably rare, vertical (mother → child), sexual contact, laboratory-related, blood transfusion, organ transplantation.
    • Trypanosoma brucei rhodesiense (t-HAT): domesticated and wild animals may be reservoirs.

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Last updated: March 5, 2019


Auwaerter, Paul G. "Trypanosoma Brucei Gambiense/rhodesiense." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540011/all/Trypanosoma_brucei_gambiense_rhodesiense.
Auwaerter PG. Trypanosoma brucei gambiense/rhodesiense. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540011/all/Trypanosoma_brucei_gambiense_rhodesiense. Accessed April 18, 2019.
Auwaerter, P. G. (2019). Trypanosoma brucei gambiense/rhodesiense. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540011/all/Trypanosoma_brucei_gambiense_rhodesiense
Auwaerter PG. Trypanosoma Brucei Gambiense/rhodesiense [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 April 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540011/all/Trypanosoma_brucei_gambiense_rhodesiense.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Trypanosoma brucei gambiense/rhodesiense ID - 540011 A1 - Auwaerter,Paul,M.D. Y1 - 2019/03/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540011/all/Trypanosoma_brucei_gambiense_rhodesiense PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -