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Used in the treatment of various forms of endogenous depression, often in conjunction with psychotherapy. Other uses include:Treatment of anxiety (doxepin, duloxetine, fluoxetine, paroxetine, sertraline, venlafaxine) Enuresis (imipramine) Chronic pain syndromes (amitriptyline, doxepin, duloxetine, imipramine, nortriptyline) Smoking cessation (bupropion) Bulimia (fluoxetine) Obsessive-compulsive disorder (fluoxetine, fluvoxamine, paroxetine, sertraline) Social anxiety disorder (paroxetine, sertraline, venlafaxine).