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inositol

General

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

Pronunciation:
ih-noh-si-tawl


Trade Name(s)

  • antialopecia factor
  • cyclohexitol
  • lipositol
  • vitamin B8

Ther. Class.
anti-rds agents
antiobsessive agents
vitamins

Common Uses

  • Respiratory distress syndrome (RDS).
  • Obsessive compulsive disorder (OCD).
  • Panic disorder.
  • Polycystic ovary syndrome.
  • Lithium-induced psoriasis.

Action

Inositol is an essential component of cell membrane phospholipids. It is a constituent of the intracellular phosphatidyl inositol second messenger system which is linked to serotonin, norepinephrine, and cholinergic receptors. It may have similar benefits as SSRIs in panic disorder and OCD. It induces ovulation by improving insulin sensitivity in women with polycystic ovary syndrome. Inositol helps psoriasis triggered by lithium through an unknown mechanism. In infants with RDS, inositol lowers inspiratory oxygen requirements, mean airway pressure, and bronchopulmonary dysplasia incidence in premature infants not receiving surfactant when compared to placebo.

Therapeutic Effect(s):

  • Improvement in OCD and panic disorder symptoms.
  • Induces ovulation in polycystic ovary syndrome.
  • Improved RDS symptoms in infants with RDS.

Pharmacokinetics

Absorption: Unknown.

Distribution: Unknown.

Metabolism and Excretion: Unknown.

Half-life: Unknown.

TIME/ACTION PROFILE

ONSETPEAKDURATION
POunknownunknownunknown

Contraindication/Precautions

Contraindicated in:

  • Hypersensitivity.

Use Cautiously in:

  • Bipolar disorder;
  • Pregnancy and lactation.

Adverse Reactions/Side Effects

CNS: headache, dizziness, fatigue

GI: nausea

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Natural Drug Interaction

Inositol levels may be ↓ by carbamazepine, lithium, and valproic acid.

Natural-Natural:

None.

Route/Dosage

PO: (Adults) Panic disorder– 12–18 grams/day. OCD– 18 grams/day. Polycystic ovary syndrome– 1200 mg/day. Lithium-induced psoriasis– 6 grams/day.

IV: Infants RDS– 80 mg/kg/day.

Availability

Injection
Powder
Capsules

Assessment

  • Assess is dependent on use; assess area appropriate for use.

Potential Diagnoses

Implementation

  • PO: Administer with meals.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Improvement in area of use.

inositol is a sample topic from the Davis's Drug Guide.

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Citation

Quiring, Courtney, et al. "Inositol." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/110145/all/inositol.
Quiring C, Sanoski CA, Vallerand AH. Inositol. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/110145/all/inositol. Accessed April 23, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Inositol. In Davis's Drug Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/110145/all/inositol
Quiring C, Sanoski CA, Vallerand AH. Inositol [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 April 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/110145/all/inositol.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - inositol ID - 110145 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/110145/all/inositol PB - F.A. Davis Company ET - 16 DB - Pediatrics Central DP - Unbound Medicine ER -