General

Pronunciation:
loo-li-kon-a-zole

Trade Name(s)

• Luzu

Ther. Class.
antifungals

Pharm. Class.
azoles

Indications

Topical treatment of interdigital tinea pedis, tinea cruris and tinea corporis.

Action

• Inhibits an enzyme necessary for ergosterol synthesis, required for fungal cell membranes.
• Antifungal action .

Therapeutic Effect(s):

Resolution of dermal fungal infection.

Active against Trichyphyton rubrum and Epidermpophyton floccosum.

Pharmacokinetics

Absorption: Small amounts are systemically absorbed.

Distribution: Unknown.

Protein Binding: >99%

Metabolism and Excretion: Unknown.

Half-life: Unknown.

TIME/ACTION PROFILE (improvement/resolution of infection)

Contraindication/Precautions

Contraindicated in:

• None noted.

Use Cautiously in:

• OB:  Lactation: Safety not established;
• Pedi:  Safety and effectiveness not established.

Adverse Reactions/Side Effects

Derm: application site reactions

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Drug-Drug

May inhibit the activity of the CYP2C19 enzymes.

Route/Dosage

Topical (Adults):  Interdigital tinea pedis Apply to affected and surrounding areas once daily for two weeks;  Tinea cruris and tinea corporis Apply to affected and surrounding areas once daily for one week.

Availability

Cream: 1%

Assessment

• Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Diagnoses

• Risk for impaired skin integrity (Indications) 
• Risk for infection (Indications) 

Implementation

• Consult health care professional for proper cleansing technique before applying medication.
• Topical  For Interdigital tinea pedis:  Apply thin layer to cover affected area and approximately 1 inch of immediate surrounding area completely daily for 2 wk.
  •  For Tinea Cruris or Tinea Corporis:  Apply thin layer to affected area and approximately 1 inch of immediate surrounding area daily for 1 wk.
  • Avoid the use of occlusive wrappings or dressings unless directed by health care professional. Wash hands after application.

Patient/Family Teaching

• Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes and vagina.
• Patients with athlete's foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
• Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
• Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
• Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Decrease in skin irritation and resolution of infection.