melatonin
General
Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
Pronunciation:
mel-uh-toh-nin
Trade Name(s)
- pineal hormone
- N-acetyl-5-methoxtryptamine
Ther. Class.
Common Uses
Sleep disorders (insomnia, jet lag, circadian rhythm disorders).
Action
Secreted by the pineal glad. Regulates secretion of growth hormone and gonadotropic hormones. It also possesses antioxidant activity.
Therapeutic Effect(s):
Improved sleep pattern.
Pharmacokinetics
Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.
TIME/ACTION PROFILE
ONSET | PEAK | DURATION | |
---|---|---|---|
PO | unknown | unknown | unknown |
Contraindication/Precautions
Contraindicated in:
- Hypersensitivity;
- Autoimmune diseases.
Use Cautiously in:
- Diabetes;
- Hypertension;
- Hypotension;
- Seizure disorders;
- OB: Safety not established in pregnancy;
- Lactation: Safety not established in breastfeeding;
- Pedi: Safety and effectiveness not established in children.
Adverse Reactions/Side Effects
CV: hypotension
GI: abdominal cramps, nausea, vomiting
Neuro: dizziness, drowsiness, excessive daytime somnolence, headache, irritability, nightmares
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Interactions
Natural Drug Interaction
- Additive sedation with CNS depressants.
- May ↑ bleeding risk with antiplatelet agents and anticoagulants.
- May interfere with the glucose-lowering effects of hypoglycemic agents.
- May ↓ effectiveness of nifedipine.
Natural-Natural:
Route/Dosage
PO (Adults): 0.3–10 mg once daily at bedtime.
Availability
Capsules: OTC
Tablets: OTC
Sublingual Tablets: OTC
Gummies: OTC
Assessment
- Assess sleep patterns before and periodically throughout therapy.
Lab Test Considerations:
Monitor blood glucose, coagulation panel, hormone panel, and lipid panel periodically during therapy.
Implementation
- PO Administer before bedtime.
Patient/Family Teaching
- Explain purpose and side effects of herb to patient. Advise patient to take at bedtime as directed.
- Advise patient to consult with health care provider before using any herbal supplement, especially when taken concurrently with Rx or OTC medications or vitamins.
- Advise patient to avoid driving and other activities requiring alertness until response to medication is known.
- Advise patient to avoid concurrent use of alcohol or other CNS depressants.
- Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding before using this herb.
Evaluation/Desired Outcomes
Improved sleep pattern.