- A decision by a patient or parent to delay or refuse a vaccine recommended by a health care provider
- Comprises a range of behaviors from unquestioning acceptance of vaccines to cautious or selective acceptance to refusal of all vaccines
- Influenced by the interaction of several factors related to: confidence, complacency, and convenience
- Confidence: lack of trust in vaccines, health care providers, and/or health care system
- Complacency: low prioritization of vaccination related to low perceived risk of vaccine preventable diseases
- Convenience: barriers to accessing immunization services (e.g., vaccine cost or difficulty getting to immunization provider)
- Majority of adults in the United States believe vaccination is extremely or very important, but increasing proportion believe vaccines are more dangerous than diseases they prevent.
- Majority of pediatricians report >1 vaccine refusal/month.
- >1/3 of pediatricians will accept requests to delay certain vaccines, but fewer than 10% agree with such requests.
- Among a cohort of undervaccinated young children, 13% were undervaccinated due to parental choice.
- Rate of infants who receive first vaccine dose at age 4 to 5 months increased from ~50/10,000 to 100/10,000 across five successive birth cohorts (2004 to 2008).
- In the 2015 to 2016 school year, exemption rates for kindergarten school entry requirements rose from 0.4% to 6.2% across U.S. states.
Because of the heterogeneity of vaccine hesitancy, there is no one singular set of risk factors. However, contributors to refusal include:
- Less experience with vaccine preventable diseases due to decreased disease incidence. This leads to underappreciation of disease risk and severity and parents may question need for vaccines.
- Vaccine safety concerns—especially as concerns about risk of vaccine—preventable diseases decreases, parents may worry more about potential risks of vaccination.
- Rapid dissemination of information increases likelihood of access to misinformation about vaccines, which may reinforce vaccine safety concerns,
- Anti-vaccine advocacy by prominent public figures that call attention to anti-vaccine beliefs.
- Increase in scientific denialism, which is rejection of facts for which there is well-established scientific consensus.
- Early communication about vaccines with parents can help identify and address concerns to prevent vaccine refusal or delay.
- Opportunities may include prenatal visits, in the nursery prior to discharge from the hospital after or at the newborn visit.
Commonly Associated Conditions
- For some parents, vaccine refusal may be associated with refusal of other health care interventions.
- Some parents may accept all recommended vaccines but request an alternative schedule. Alternative vaccine schedules spread out the recommended vaccine doses, resulting in immunization delay for some vaccines.
- Reasons for request of alternative vaccine schedules:
- Belief that receiving multiple injections at same time overwhelms the immune system
- Belief that recommended schedule exposes infants to too much aluminum
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Cabana, Michael D., editor. "Vaccine Refusal." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618203/all/Vaccine_Refusal.
Vaccine Refusal. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618203/all/Vaccine_Refusal. Accessed May 30, 2023.
Vaccine Refusal. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618203/all/Vaccine_Refusal
Vaccine Refusal [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2023 May 30]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618203/all/Vaccine_Refusal.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Vaccine Refusal ID - 618203 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618203/all/Vaccine_Refusal PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -