Rickets Tables and Figures
Assessment of Etiology of Rickets Based on Laboratory Results
Ca | Phos | Alk phos | iPTH | 25-(OH)D | 1,25-(OH)2D | Urine Ca/Cr | TRP | |
---|---|---|---|---|---|---|---|---|
Nutritional/insufficient sunlight | N or ↓ | ↓ | ↑ | ↑ | ↓ | ↑ | ↓ | ↑ |
Malabsorption | N or ↓ | ↓ | ↑ | ↑ | ↓ | ↑ | ↓ | ↑ |
Renal tubular defects | N or ↓ | ↓ | ↑ | ↑ | N | ↑ | ↑ | N or ↓ |
Altered vitamin D metabolism | N or ↓ | ↓ | ↑ | ↑ | ↓ | ↑ | ↓ | ↑ |
Genetic forms of rickets | ||||||||
X-linked, AD, and AR hypophosphatemic rickets | N | ↓ | ↑ | N or ↑ | N | N or ↑ | N or ↓ | ↓ |
1a-hydroxylase deficiency | ↓ | ↓ | ↑ | ↑ | N | ↓ | ↓ | ↑ |
Vitamin D receptor mutations (vitamin D resistance) | ↓ | ↓ | ↑ | ↑ | N | ↑ | ↓ | ↑ |
Hereditary hypophosphatemic rickets with hypercalciuria | N or ↓ | ↓ | ↑ | ↑ | N | ↑ | ↑ | ↓ |
Hypophosphatasia | N or ↑ | N or ↑ | ↓ | N or ↓ | N | N or ↓ | N or ↑ | N |
Ca, calcium; phos, phosphorus; alk phos, alkaline phosphatase; iPTH, intact parathyroid hormone; 25-(OH)-D, 25-hydroxy vitamin D; 1,25-(OH)2-D, 1,25-dihydroxy vitamin D; Ca/Cr, calcium/creatinine ratio; TRP, tubular reabsorption of phosphorus ([1 − (U phos × P Cr/U Cr × S Phos)] × 100, normal 85–95%); AD, autosomal dominant; AR, autosomal recessive; N, normal.
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Citation
Cabana, Michael D., editor. "Rickets Tables and Figures." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618138/all/Rickets_Tables_and_Figures.
Rickets Tables and Figures. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618138/all/Rickets_Tables_and_Figures. Accessed December 1, 2024.
Rickets Tables and Figures. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618138/all/Rickets_Tables_and_Figures
Rickets Tables and Figures [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2024 December 01]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618138/all/Rickets_Tables_and_Figures.
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