Type your tag names separated by a space and hit enter

    Multicystic Dysplastic Kidney

    Multicystic Dysplastic Kidney is a topic covered in the 5-Minute Pediatric Consult.

    To view the entire topic, please or purchase a subscription.

    Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

    Pediatrics Central

    -- The first section of this topic is shown below --

    Basics

    Description

    • Multicystic dysplastic kidney (MCDK) disease is the most severe type of cystic renal dysplasia and is characterized by multiple, noncommunicating cysts which are divided by dysplastic tissue.
    • In general, there is no functioning renal tissue in a MCDK.
    • Involutes over time (usually within the first 5 years)

    Epidemiology

    • Incidence is 0.3 to 1 in 1,000 live births
      • Most cases are detected antenatally.
    • Affects boys > girls
    • Left kidney > right kidney
      • Usually unilateral but can be bilateral

    Pathophysiology

    • Initial growth of the ureteric bud is normal; then renal development halts at a later stage.
    • Histology shows disordered renal tissue with areas of undifferentiated mesenchymal cells, abnormal differentiation (i.e., cartilage), rare nephrons.
    • Etiology unknown; recent studies suggest genetic cause.

    Commonly Associated Conditions

    Associated anomalies of contralateral GU tract include the following:

    • Vesicoureteral reflux (VUR), most common, occurs in ~25%.
    • Renal hypoplasia
    • Ureterocele
    • Ureteropelvic junction (UPJ) obstruction
    • Genital anomalies

    -- To view the remaining sections of this topic, please or purchase a subscription --

    Citation

    Cabana, Michael D., editor. "Multicystic Dysplastic Kidney." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618136/all/Multicystic_Dysplastic_Kidney.
    Multicystic Dysplastic Kidney. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618136/all/Multicystic_Dysplastic_Kidney. Accessed April 21, 2019.
    Multicystic Dysplastic Kidney. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618136/all/Multicystic_Dysplastic_Kidney
    Multicystic Dysplastic Kidney [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618136/all/Multicystic_Dysplastic_Kidney.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Multicystic Dysplastic Kidney ID - 618136 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/618136/all/Multicystic_Dysplastic_Kidney PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -