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Spondyloarthropathy is a topic covered in the 5-Minute Pediatric Consult.

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A group of rheumatic diseases characterized by axial and/or peripheral arthritis and enthesitis (inflammation at the bony insertion of tendons and ligaments)

  • Enthesitis-related arthritis
  • Ankylosing spondylitis (AS)
  • Psoriatic arthritis
  • Inflammatory bowel disease–associated arthropathy
  • Reactive arthritis


  • Spondyloarthritis accounts for 15–20% of juvenile arthritis or more.
  • Nonradiographic axial spondyloarthritis (male = female)
  • AS typically affects adolescent boys (male-to-female ratio is 2 to 3:1).


Prevalence of AS mirrors that of HLA-B27 in a population

  • European descent 8% HLA-B27+ and 0.5% AS

Risk Factors


  • HLA-B27 associated
  • Risk of developing ERA with HLA-B27 is approximately 1–3%. Usually, there is a family history of a male relative with the disease.
  • HLA-B27–positive with a family history of AS have a 10-fold increased risk of AS compared to HLA-B27–positive person with no family history.


  • Inflammatory synovitis of joints and inflammation at sites of ligament and tendon attachment to bone (entheses).
  • Progression to ankylosis is a result of calcification of the anterior and posterior longitudinal ligaments of the spine.


  • Autoimmune or autoinflammatory arthritis of unknown etiology, likely multifactorial
  • Microbiome may play a role in disease.

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Cabana, Michael D., editor. "Spondyloarthropathy." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617749/all/Spondyloarthropathy.
Spondyloarthropathy. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617749/all/Spondyloarthropathy. Accessed April 22, 2019.
Spondyloarthropathy. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617749/all/Spondyloarthropathy
Spondyloarthropathy [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617749/all/Spondyloarthropathy.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Spondyloarthropathy ID - 617749 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617749/all/Spondyloarthropathy PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -