Pruritus, or itch, is one of the most frequent dermatologic complaints. It is an unpleasant sensation characterized by the reflexive behavior to scratch and is a symptom associated with numerous inflammatory and infectious skin diseases. However, generalized and persistent pruritus without or with minimal skin changes may be a presenting feature of a variety of systemic diseases.
- Itch-specific peripheral nerves are unmyelinated afferent C-fibers.
- Pruritus is dependent on the complex interplay of neuroinflammatory modulators among peripheral nerves, keratinocytes, and leukocytes as well as central nervous system (CNS) processing.
- There are numerous mediators of pruritus, although histamine is the prototypical pharmacologic target for many patients.
- Dermatologic: arising from skin disease
- Systemic: arising from noncutaneous organ systems including metabolic causes, drugs, and multifactorial disorders
- Neurogenic: arising from disorders of the central or peripheral nervous system
- Psychogenic: arising from primary psychiatric disorders
- Mixed: coexistence of more than one etiology of pruritus
- Idiopathic: pruritus of uncertain etiology
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Cabana, Michael D., editor. "Pruritus." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617694/all/Pruritus.
Pruritus. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617694/all/Pruritus. Accessed June 5, 2023.
Pruritus. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617694/all/Pruritus
Pruritus [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2023 June 05]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617694/all/Pruritus.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Pruritus ID - 617694 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617694/all/Pruritus PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -