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- A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
- Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).
Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ~70% of primary immune deficiencies.
Genetic defects have been identified in many cases (see “Differential Diagnosis”).
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Cabana, Michael D., editor. "Hypogammaglobulinemia." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617670/all/Hypogammaglobulinemia.
Hypogammaglobulinemia. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617670/all/Hypogammaglobulinemia. Accessed April 23, 2019.
Hypogammaglobulinemia. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617670/all/Hypogammaglobulinemia
Hypogammaglobulinemia [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617670/all/Hypogammaglobulinemia.
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