Hypogammaglobulinemia is a topic covered in the 5-Minute Pediatric Consult.

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  • A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
  • Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).


Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ~70% of primary immune deficiencies.

Risk Factors

Genetic defects have been identified in many cases (see “Differential Diagnosis”).

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TY - ELEC T1 - Hypogammaglobulinemia ID - 617670 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617670/all/Hypogammaglobulinemia PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -