Type your tag names separated by a space and hit enter


Cirrhosis is a topic covered in the 5-Minute Pediatric Consult.

To view the entire topic, please or purchase a subscription.

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

Pediatrics Central

-- The first section of this topic is shown below --



  • Cirrhosis is the end stage of progressive hepatic necrosis, fibrosis, and regenerative nodule formation that may occur as a result of many different liver diseases.
  • Results in distortion of liver architecture and compression of hepatic vascular and biliary structures
  • Cirrhosis is clinically defined by outcomes as either compensated or decompensated:
    • Compensated cirrhosis: typically asymptomatic with normal synthetic function
    • Decompensated cirrhosis: defined as loss of normal synthetic function, development of jaundice, and/or the clinical complications of portal hypertension such as ascites, variceal hemorrhage, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, and portopulmonary hypertension
  • In its decompensated form/advanced form, cirrhosis is irreversible and often requires liver transplantation for survival of the patient.


  • There are varying causes of cirrhosis; accordingly, no specific epidemiologic pattern can be identified.
  • Cirrhosis due to chronic hepatitis C virus (HCV) infection, alcoholic liver disease, and nonalcoholic fatty liver disease (NAFLD) are the most common indications for liver transplantation in adults.
  • Biliary cirrhosis due to biliary atresia is the most common indication for liver transplantation in children.

Risk Factors


  • Many distinct genetic disorders can cause cirrhosis, such as Wilson disease and hereditary hemochromatosis.
  • Human leukocyte antigen (HLA) associations have been identified in several autoimmune disorders, including sclerosing cholangitis and autoimmune hepatitis.

-- To view the remaining sections of this topic, please or purchase a subscription --


Cabana, Michael D., editor. "Cirrhosis." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617662/all/Cirrhosis.
Cirrhosis. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617662/all/Cirrhosis. Accessed April 23, 2019.
Cirrhosis. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617662/all/Cirrhosis
Cirrhosis [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617662/all/Cirrhosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Cirrhosis ID - 617662 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617662/all/Cirrhosis PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -