Type your tag names separated by a space and hit enter

Tetralogy of Fallot

Tetralogy of Fallot is a topic covered in the 5-Minute Pediatric Consult.

To view the entire topic, please or purchase a subscription.

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

Pediatrics Central

-- The first section of this topic is shown below --



Anatomic hallmark is anterior malalignment of infundibular (outlet) septum, which results in

  • A large and unrestrictive ventricular septal defect (VSD)
  • Various degrees of right ventricular outflow tract obstruction (RVOTO)
  • Overriding aorta
  • Right ventricular hypertrophy (RVH) secondary to exposure to systemic pressure


  • The most common cyanotic congenital heart disease
  • 3.5–10% of all congenital heart disease

Risk Factors


About 20% of cases of tetralogy of Fallot are associated with a chromosome 22q11 microdeletion or duplication.


  • Severity of clinical signs and symptoms depends on the degree of RVOTO and related right-to-left shunt at the VSD.
  • Physiology is a spectrum ranging from too little pulmonary blood flow and right-to-left shunt at the VSD due to severe RVOT obstruction (“blue tet”) to moderate pulmonary overcirculation and left-to-right shunt at the VSD with minimal RVOTO (“pink tet”).

Commonly Associated Conditions

  • May be associated with other syndromes including trisomy 21, Alagille syndrome, fetal alcohol syndrome, and those involving a variety of limb abnormalities
  • Tetralogy of Fallot may also be associated with midline abdominal defects (e.g., omphalocele) as in the pentalogy of Cantrell.

-- To view the remaining sections of this topic, please or purchase a subscription --


Cabana, Michael D., editor. "Tetralogy of Fallot." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617579/all/Tetralogy_of_Fallot.
Tetralogy of Fallot. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617579/all/Tetralogy_of_Fallot. Accessed April 20, 2019.
Tetralogy of Fallot. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617579/all/Tetralogy_of_Fallot
Tetralogy of Fallot [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 20]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617579/all/Tetralogy_of_Fallot.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Tetralogy of Fallot ID - 617579 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617579/all/Tetralogy_of_Fallot PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -