Pyloric Stenosis
Basics
Description
Hypertrophy of the muscular layers of the pylorus with elongation and thickening, leading to projectile nonbilious emesis and gastric outlet obstruction
Epidemiology
- Usually presents between the 3rd and 10th week of life
- Male-to-female ratio 4:1, with 1st-born males more affected
- More common in Caucasians
Incidence
~2 to 4 per 1,000 live births in Western populations
Pathophysiology
- Marked muscle hypertrophy and hyperplasia primarily involving the circular layer and hyperplasia of the underlying mucosa
- Growth of abnormally contorted and thickened nerve fibers and/or lack of neural elements
- Net result is either partial or complete obstruction of the pyloric channel.
Etiology
- No definitive causative factors have been identified despite considerable research.
- Genetic predisposition evidenced by variability among races, male preponderance, and genetic syndromes with pyloric stenosis
- Children of affected fathers are affected 3–5%, whereas affected mothers are associated with a 7–20% incidence.
- Several growth factors and gastrointestinal (GI) peptides, including gastrin and elevated acid levels, as well as increases in substance P, epidermal growth factor (EGF), transforming growth factor alpha (TGF α), and insulin-like growth factor-1 (IGF-1), have been implicated.
- Erythromycin estolate given for postexposure prophylaxis for pertussis may cause strong gastric and pyloric contractions that induce hypertrophy. Erythromycin exposure to lactating mothers is associated with breastfed infants who have an increased incidence of pyloric stenosis.
- Decreases in nerve differentiation, reduced density of neural elements, and deficiency of nitric oxide–induced muscle relaxation have been implicated.
Commonly Associated Conditions
Esophageal atresia and malrotation was noted in 5% of infants with pyloric stenosis.
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Cabana, Michael D., editor. "Pyloric Stenosis." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617528/all/Pyloric_Stenosis.
Pyloric Stenosis. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617528/all/Pyloric_Stenosis. Accessed September 7, 2024.
Pyloric Stenosis. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617528/all/Pyloric_Stenosis
Pyloric Stenosis [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2024 September 07]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617528/all/Pyloric_Stenosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Pyloric Stenosis
ID - 617528
ED - Cabana,Michael D,
BT - 5-Minute Pediatric Consult
UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617528/all/Pyloric_Stenosis
PB - Wolters Kluwer
ET - 8
DB - Pediatrics Central
DP - Unbound Medicine
ER -