Irritable Bowel Syndrome
- Irritable bowel syndrome (IBS) is a common functional GI tract disorder where defecation is disordered and associated with abdominal discomfort.
- IBS is characterized by abdominal pain, bloating, diarrhea, or constipation
- Symptoms of IBS do not result from inflammatory, infectious, metabolic, or anatomic causes. However, there can be overlap with other conditions.
- Symptoms typically exacerbated by stress or particular foods (i.e., spices, fatty foods, caffeine, certain carbohydrates, etc.).
- 10–15% of the general population is affected to some degree by IBS.
- Prevalence estimates vary based on whether the study is community-based or practice-based.
- Higher estimates in the community reflect the fact that many people do not seek medical care for their IBS symptoms.
- Prevalence is also based on whether Manning, Rome II, or Rome III criteria are used.
- More common in females
- IBS occurs in children.
- 6% of middle school students
- 14% of high school students
- Prior history of bacterial enteritis
- History of abuse or trauma
- IBS considered a disorder of GI function relating to motility, sensation, and/or perception
- Best model is a biopsychosocial construct with dysregulation of the gut-brain homeostasis affected bidirectionally by both peripheral and central factors.
- The pathogenesis of IBS is believed to be multifactorial and include the following:
- Abnormal gut motility
- Bacterial overgrowth
- Visceral hypersensitivity
- Behavioral response
- Microscopic inflammation
- Dysregulation of brain-gut axis
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