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Ulcerative Colitis

Ulcerative Colitis is a topic covered in the 5-Minute Pediatric Consult.

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Ulcerative colitis (UC) is a chronic, relapsing, inflammatory disease of the colon, which extends continuously from the rectum proximally to a varying extent. UC is categorized as an inflammatory bowel disease (IBD), along with Crohn disease (CD). Unlike CD, UC does not affect the small bowel.


  • The incidence of pediatric-onset UC is between 1 and 4 per 100,000 children per year in most North American and European regions.
  • Roughly 15–20% of patients with UC develop the disease before the age of 18 years.
  • Incidence peaks between 15 and 30 years of age.


The precise cause of UC, as with IBD in general, is unknown but is thought to involve both genetic predisposition and environmental triggers.

Risk Factors


  • Family history of IBD in ~15–20% of patients with UC
  • Higher concordance in monozygotic than in dizygotic twins
  • Genome-wide association studies (GWAS) have identified multiple loci associated with UC. Mutations in genes involving intestinal barrier functions are seen in UC more often than healthy controls.

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Cabana, Michael D., editor. "Ulcerative Colitis." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617358/all/Ulcerative_Colitis.
Ulcerative Colitis. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617358/all/Ulcerative_Colitis. Accessed April 22, 2019.
Ulcerative Colitis. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617358/all/Ulcerative_Colitis
Ulcerative Colitis [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617358/all/Ulcerative_Colitis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Ulcerative Colitis ID - 617358 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617358/all/Ulcerative_Colitis PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -