- Appearance of pubic hair before age 8 years in girls and age 9 years in boys with elevated adrenal androgens (dehydroepiandrosterone [DHEA] or dehydroepiandrosterone-sulfate [DHEA-S])
- Some data suggest that the age of normal sexual development onset in girls is younger than previously recognized, but lowering of the traditionally accepted limits remains subject to debate.
- Axillary hair, acne, and apocrine sweat gland secretion are not always present with premature adrenarche.
- No other signs of sexual development should be present.
- Presence of breast development in girls or testicular enlargement in boys suggests precocious puberty and not premature adrenarche.
- Occurs independently of hypothalamic–pituitary–gonadal axis activation seen with true puberty
- Often sporadic
- Familial patterns suggesting recessive and dominant inheritance have been described.
- Concentrations of adrenal steroids such DHEA or DHEA-S increase earlier than typically seen in normal puberty.
- Note: Zona reticularis of adrenal normally begins to increase androgen secretion at age 6 to 8 years.
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Cabana, Michael D., editor. "Premature Adrenarche." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche.
Premature Adrenarche. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche. Accessed June 4, 2023.
Premature Adrenarche. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche
Premature Adrenarche [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2023 June 04]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Premature Adrenarche ID - 617222 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -