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Premature Adrenarche

Premature Adrenarche is a topic covered in the 5-Minute Pediatric Consult.

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Basics

Description

  • Appearance of pubic hair before age 8 years in girls and age 9 years in boys with elevated adrenal androgens (dehydroepiandrosterone [DHEA] or dehydroepiandrosterone-sulfate [DHEA-S])
  • Some data suggest that the age of normal sexual development onset in girls is younger than previously recognized, but lowering of the traditionally accepted limits remains subject to debate.
  • Axillary hair, acne, and apocrine sweat gland secretion are not always present with premature adrenarche.
  • No other signs of sexual development should be present.
  • Presence of breast development in girls or testicular enlargement in boys suggests precocious puberty and not premature adrenarche.
  • Occurs independently of hypothalamic–pituitary–gonadal axis activation seen with true puberty

Risk Factors

Genetics

  • Often sporadic
  • Familial patterns suggesting recessive and dominant inheritance have been described.

Pathophysiology

  • Concentrations of adrenal steroids such DHEA or DHEA-S increase earlier than typically seen in normal puberty.
  • Note: Zona reticularis of adrenal normally begins to increase androgen secretion at age 6 to 8 years.

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Citation

Cabana, Michael D., editor. "Premature Adrenarche." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche.
Premature Adrenarche. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche. Accessed April 21, 2019.
Premature Adrenarche. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche
Premature Adrenarche [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Premature Adrenarche ID - 617222 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617222/all/Premature_Adrenarche PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -