- Ascites is defined as a pathologic accumulation of intraperitoneal fluid.
- Peritoneal fluid formation is a dynamic process of production and absorption.
- In children, ascites is usually the result of liver or renal disease.
- In adults, ascites is most often due to portal hypertension from cirrhosis.
- Ascites is the most common of the three major complications of cirrhosis; the other two complications of cirrhosis are hepatic encephalopathy and variceal hemorrhage.
- Normal circulation
- Blood enters the liver from the hepatic artery and portal vein, perfuses the hepatic sinusoids, and exits the liver via the hepatic veins.
- Hepatic lymph, formed by the filtration of sinusoidal plasma into the space of Disse, drains from the liver via the transdiaphragmatic lymphatic vessels to the thoracic duct.
- Hepatic lymph is isosmotic to plasma, as the sinusoidal endothelium is highly permeable to albumin.
- In the intestine, the mesenteric capillary membrane is impermeable to albumin. The osmotic gradient favors the return of interstitial fluid/lymph into the capillary.
- Intestinal lymph from regional lymphatics combines with hepatic lymph in the thoracic duct.
- Portal hypertension
- Ascitic fluid production is due to a net transfer of fluid that exceeds the drainage capacity of the lymphatics.
- Cirrhotic ascites results from three pathophysiologic process:
- Portal hypertension
- Vasodilation: mediated predominantly by nitric oxide
- Hyperaldosteronism: Decreased effective volume sensed by the kidneys stimulates the renin-angiotensin-aldosterone system, leading to increased sympathetic activity and antidiuretic hormone secretion.
- Noncirrhotic ascites can be the result of the following:
- Proteinaceous material produced by malignant cells or by inflammation of visceral and/or parietal peritoneum: peritoneal carcinomatosis, tuberculous ascites
- Obstruction of lymphatic flow by mass, tumor, or external pressure
- Impaired portal flow: right-sided heart failure, Budd-Chiari syndrome, portal venous malformations
- Decreased effective arterial blood volume: heart failure
- Decreased oncotic pressure/hypoalbuminemia: nephrotic syndrome, protein-losing enteropathy, severe malnutrition
- Primary (congenital) abnormalities of the lymphatics, metabolic disorders (lysosomal storage diseases including sialidosis, Wolman disease, GM1 gangliosidosis, Gaucher disease, and Niemann-Pick type C)
- Rupture of intra-abdominal viscus or peritoneal/mesenteric cyst, bowel perforation, ureteral rupture
Accumulation of fluid occurs with the following:
- Inflammatory conditions (e.g., mesenteric adenitis, tuberculosis, pancreatitis, secondary to inflammation of visceral, and/or parietal peritoneum)
- Portal hypertension or obstruction of portal vein flow and/or lymphatic flow by mass, tumor, or external pressure; tumors of abdominal viscera, retroperitoneum, thorax, or mediastinum (often characterized by chylous ascites)
- Infectious processes: abscess, tuberculosis, Chlamydia infection, schistosomiasis
- Gastrointestinal: infarcted bowel/perforation, pancreatitis, ruptured pancreatic duct, parenchymal liver disease
- Gynecologic: ovarian tumors, torsion, or rupture
- Renal: nephrotic syndrome, obstructive uropathy, perforated urinary tract, peritoneal dialysis
- Cardiac: congestive heart failure (CHF), constrictive pericarditis, inferior vena cava web
- Neoplastic: lymphoma, neuroblastoma
- Miscellaneous: systemic lupus erythematous, eosinophilic ascites, chylous ascites, hypothyroidism, ventriculoperitoneal shunt
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Cabana, Michael D., editor. "Ascites." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617093/all/Ascites.
Ascites. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617093/all/Ascites. Accessed June 4, 2023.
Ascites. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617093/all/Ascites
Ascites [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2023 June 04]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617093/all/Ascites.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Ascites ID - 617093 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617093/all/Ascites PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -