Leukocytosis
Basics
Description
Leukocytosis refers to a total white blood cell (WBC) count above the normal range for age.
Risk Factors
- Very low-birth-weight neonates
- Immunodeficiencies or immunocompromised states
- Inflammatory disorders
- Autoimmune disorders
ALERT
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.
Pathophysiology
Leukocytosis results from increased marrow production, demargination, prolonged cell survival, and/or defective extravascularization in response to external stimuli or, less commonly, from an underlying marrow disorder.
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Citation
Cabana, Michael D., editor. "Leukocytosis." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617083/1.1/Leukocytosis.
Leukocytosis. In: Cabana MDM, ed. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617083/1.1/Leukocytosis. Accessed October 11, 2024.
Leukocytosis. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ed.). Wolters Kluwer. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617083/1.1/Leukocytosis
Leukocytosis [Internet]. In: Cabana MDM, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2024 October 11]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617083/1.1/Leukocytosis.
* Article titles in AMA citation format should be in sentence-case
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T1 - Leukocytosis
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ED - Cabana,Michael D,
BT - 5-Minute Pediatric Consult
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PB - Wolters Kluwer
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DB - Pediatrics Central
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