Johns Hopkins ABX Guide
Talaromyces marneffei
MICROBIOLOGY
- Dimorphic fungus, recent taxonomy change to Talaromyces from Penicillium subgenus Biverticillium, reflects phylogenetic distinction from other subgenera of Penicillium. Disease still referred to as penicilliosis.
- Mold at 25oC with short, hyaline, septate and branched hyphae;
- Yeast at 37oC with cerebriform, smooth, light tan colonies; secretes bright red pigment that appears pink as it diffuses into agar.
- Yeast form 3-6 x 2 µm, sausage-shaped with central transverse septum.
- T. marneffei geographically distributed across tropical SE Asia. Endemic in: NE India, Thailand, Vietnam, Myanmar, Laos, Cambodia, Indonesia, Hong Kong, southern China.
- Reservoir: Bamboo rats
- Found in 100% of sample of hoary bamboo rats (cultured from lungs, liver and spleen) in Guangxi Province, China.[13]
- Organism also isolated from soil of bamboo rats’ burrows.
- Transmitted primarily via inhalation; also direct inoculation, possibly ingestion.
- Proliferates in macrophages and spreads via reticuloendothelial system.[3]
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Last updated: January 14, 2020
Citation
Spacek, Lisa A. "Talaromyces Marneffei." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540744/all/Talaromyces_marneffei.
Spacek LA. Talaromyces marneffei. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540744/all/Talaromyces_marneffei. Accessed December 3, 2023.
Spacek, L. A. (2020). Talaromyces marneffei. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540744/all/Talaromyces_marneffei
Spacek LA. Talaromyces Marneffei [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2023 December 03]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540744/all/Talaromyces_marneffei.
* Article titles in AMA citation format should be in sentence-case
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PB - The Johns Hopkins University
DB - Pediatrics Central
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