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Fusobacterium species

Fusobacterium species is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Anaerobic, Gram-negative bacteria
    • Slender rods with pointed ends [Fig] but may be pleomorphic (coccoid, spheroid).
      • May grow under anaerobic conditions on a number of media: e.g., CVE (crystal-violet erythromycin) agar, modified chopped meat medium added with 2% agar or Brucella blood agar.
    • Multiple species but usually two account for most human disease:
      • Fusobacterium nucleatum: may be part of dental plaque flora, also cause of invasive infection of head/neck and elsewhere.
      • F. necrophorum: cause of pharyngotonsillitis, Lemierre syndrome (septic jugular vein thrombophlebitis) and peritonsillar abscess, especially children and young adults
      • Other: F. mortiferum (occasional cause bacteremia)
    • Sensitive to colistin and kanamycin, which distinguishes from Bacteroides and Porphyromonas.
  • Produces significant LPS which may account for virulence.
  • Historically, thought to be part of normal human flora, now some believe to be more likely a pathogen if recovered, especially F. nucleatum.

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Last updated: April 5, 2017

Citation

"Fusobacterium Species." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species.
Fusobacterium species. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species. Accessed June 24, 2019.
Fusobacterium species. (2017). In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species
Fusobacterium Species [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 June 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Fusobacterium species ID - 540675 Y1 - 2017/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -