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Aggregatibacter species

Aggregatibacter species is a topic covered in the Johns Hopkins ABX Guide.

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  • Aggregatibacterspp. are normal residents of human oropharyngeal flora (especially dental plaques and gingiva), sometimes urogenital flora. Member of Pasteurellaceae family.
  • Aggregatibacter actinomycetemcomitans (Aa) is a facultative Gram-negative, slowly growing coccobacillus.
    • Formerly known as Actinobacillus actinomycetemcomitans, member of HACEK group. Earlier literature called the organism Haemophilus actinomycetemcomitans.
    • Original name due to descriptions of infections with actinomycotic-like presentations.
      • When isolated in an abscess, almost always found in conjunction with Actinomyces spp.
    • Generally easily isolated, but a slow grower and may need > 7d incubation.
    • Most common cause of Aggregatibacter endocarditis.
  • A. aphrophilus: formerly Haemophilus aphrophilus, is second most common cause of Aggregatibacter endocarditis. Most common in this group to be a cause of brain abscess.
  • A. paraphrophilus: formerly Haemophilus paraphrophilus, less common cause of endocarditis of this species (usually mitral valve), may also cause brain abscess. Also found in GI tract.
  • A. segnis: uncommon commensal in the oropharynx, rare cause of endocarditis, bacteremia.
  • A. urae: meningitis reported.

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Last updated: February 2, 2017


Auwaerter, Paul G. "Aggregatibacter Species." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species.
Auwaerter PG. Aggregatibacter species. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species. Accessed June 25, 2019.
Auwaerter, P. G. (2017). Aggregatibacter species. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species
Auwaerter PG. Aggregatibacter Species [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 June 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species.
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TY - ELEC T1 - Aggregatibacter species ID - 540669 A1 - Auwaerter,Paul,M.D. Y1 - 2017/02/02/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -