Johns Hopkins ABX Guide
Severe Acute Respiratory Syndrome [SARS-CoV-1]
PATHOGENS
- SARS-associated coronavirus (SARS-CoV-1). Respiratory pathogen with spread by airborne droplet transmission.
- RNA enveloped virus; note that the coronavirus causing SARS is separate from those previously reported to cause human or animal illness.
- First reported in SE Asia in February 2003. Last known human case in China, April 2004.
- Declared a select agent by CDC (2012, select agent is a bacterium, virus or toxin that has the potential to pose a severe threat to public health and safety).
- Although coronavirus and metapneumovirus, and other bacterial and viral (influenza) pathogens have also been co-isolated from patients, SARS-CoV is considered the causative agent.
- Human coronavirus (MERS-CoV) isolated in 2012 is not the infectious agent of SARS. See the Middle East respiratory syndrome coronavirus module for additional details.
- Novel coronavirus SARS-CoV-2 causing COVID-19 illness; see separate module for details.
- Closely related genetically to SARS-CoV-1.
- Animal reservoir initially thought to be the civet cat; the latest information suggests the horseshoe bat is implicated in transmitting this infection to humans.
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Last updated: December 14, 2022
Citation
Auwaerter, Paul G. "Severe Acute Respiratory Syndrome [SARS-CoV-1]." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540494/all/Severe_Acute_Respiratory_Syndrome_[SARS_CoV_1].
Auwaerter PG. Severe Acute Respiratory Syndrome [SARS-CoV-1]. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540494/all/Severe_Acute_Respiratory_Syndrome_[SARS_CoV_1]. Accessed December 13, 2024.
Auwaerter, P. G. (2022). Severe Acute Respiratory Syndrome [SARS-CoV-1]. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540494/all/Severe_Acute_Respiratory_Syndrome_[SARS_CoV_1]
Auwaerter PG. Severe Acute Respiratory Syndrome [SARS-CoV-1] [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2024 December 13]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540494/all/Severe_Acute_Respiratory_Syndrome_[SARS_CoV_1].
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