Helicobacter pylori
PATHOGENS
- Helicobacter pylori: attaches to gastric cells inducing inflammation and cytokine production.
- Culture: if performed, typically is done following treatment failure.
- Requires endoscopy with gastric biopsy, most frequently from the antrum.
- The optimal specimen is to place in culture within three hours of collection.
- Specimen transport can be done in Brucella broth with 20% glycerol.
- The most frequently employed culture media is Brucella or Columbia agar with 7-10% blood to improve growth in a 5-10% oxygen environment.
- Cultures are held for up to 10 days due to slow growth.
- Requires endoscopy with gastric biopsy, most frequently from the antrum.
- Antimicrobial characteristics:
- H. pylori is intrinsically resistant to sulfonamides, trimethoprim and vancomycin.
- Metronidazole resistance is estimated at 22-39%, 37% commonly cited in U.S. populations.
- Clarithromycin resistance is ~11-12%; in some studies, up to 24%.
- Amoxicillin or tetracycline resistance remains less common.
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Last updated: April 16, 2023
Citation
Auwaerter, Paul. "Helicobacter Pylori." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540252/3.0/Helicobacter_pylori.
Auwaerter P. Helicobacter pylori. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540252/3.0/Helicobacter_pylori. Accessed December 5, 2024.
Auwaerter, P. (2023). Helicobacter pylori. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540252/3.0/Helicobacter_pylori
Auwaerter P. Helicobacter Pylori [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2024 December 05]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540252/3.0/Helicobacter_pylori.
* Article titles in AMA citation format should be in sentence-case
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