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Francisella tularensis

Valeria Fabre Fabre, M.D., John G. Bartlett, M.D.
Francisella tularensis is a topic covered in the Johns Hopkins ABX Guide.

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  • Small, pleomorphic, intracellular and extracellular fastidious aerobic Gram-negative coccobacillus [Fig 1].
  • Culture: poor or no growth on standard media.
    • Media most often employed: Thayer-Martin, BCYE or chocolate agar with addition of cysteine and/or cysteine (thioglycolate).
      • MacConkey does not yield growth.
    • Slow grower, may require CO2 supplementation.
  • Considered an important laboratory hazard to laboratory personnel requiring specialized safety procedures. Notify lab if considering diagnosis when submitting specimens; higher level labs may be required.
  • Four recognized subspecies that vary in location and virulence:
    • F. tularensis: distinguished by PCR.
      • Biovar tularensis (Type A), typically associated with lagomorphs (hares, rabbits, pikas)
      • Biovar holarctica (B), frequently associated with rodents and aquatic environments
      • Biovar mediasiatica and subspecies novicida

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Last updated: February 5, 2019


Fabre, Valeria Fabre, and John G Bartlett. "Francisella Tularensis." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis.
Fabre V, Bartlett JG. Francisella tularensis. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis. Accessed June 25, 2019.
Fabre, V., & Bartlett, J. G. (2019). Francisella tularensis. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis
Fabre V, Bartlett JG. Francisella Tularensis [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 June 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Francisella tularensis ID - 540233 A1 - Fabre,Valeria Fabre,M.D. AU - Bartlett,John,M.D. Y1 - 2019/02/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -