Johns Hopkins ABX Guide
Daptomycin
Daptomycin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[9]
- Note: daptomycin should not be used for the treatment of pneumonia
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[9]
- Note: daptomycin should not be used for the treatment of pneumonia
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Last updated: March 8, 2020
Citation
Avdic, Edina. "Daptomycin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
Avdic E. Daptomycin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin. Accessed May 11, 2021.
Avdic, E. (2020). Daptomycin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin
Avdic E. Daptomycin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2021 May 11]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
* Article titles in AMA citation format should be in sentence-case
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