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    Burkholderia pseudomallei

    Paul Auwaerter, M.D.
    Burkholderia pseudomallei is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Aerobic Gram-negative rod.
      • B. pseudomallei, member of Burkholderia genus.
      • Two other members, B. thailandensis (SE Asia, Australia), B. oklahomensis (Midwest U.S.), seen in environmental samples, unclear if cause of disease.
    • Cause of melioidosis, mostly commonly seen in tropical climates of southeast Asia and northern Australia but described elsewhere including South and Central America, Africa.
      • Regions of greatest prevalence: Northern Territory of Australia, northeast Thailand.
    • Commonly found in surface waters and muddy soils but mechanism of transmission remains unclear.
      • Described as colonizing rhizospheres and plant structures
    • Human cases increase significantly during times of heavy rainfall.
      • Regular contact with soil and water are risk factors.
        • Increased risk with diabetes, COPD, alcoholism, chronic renal disease, thalassemia, malignancy, immunosuppression.
      • Acquired by inhalation, traumatic inoculation or ingestion.
      • Transmission to infants through breast feeding described in mothers suffering from mastitis.
    • Culturing methods in laboratories:
      • Ashdown’s media favored for non-sterile specimens such as respiratory.
      • B. cepacia-selective media an alternative

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    Last updated: January 31, 2016

    Citation

    Auwaerter, Paul. "Burkholderia Pseudomallei." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540071/all/Burkholderia_pseudomallei.
    Auwaerter P. Burkholderia pseudomallei. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540071/all/Burkholderia_pseudomallei. Accessed April 18, 2019.
    Auwaerter, P. (2016). Burkholderia pseudomallei. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540071/all/Burkholderia_pseudomallei
    Auwaerter P. Burkholderia Pseudomallei [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 April 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540071/all/Burkholderia_pseudomallei.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Burkholderia pseudomallei ID - 540071 A1 - Auwaerter,Paul,M.D. Y1 - 2016/01/31/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540071/all/Burkholderia_pseudomallei PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -