Burkholderia mallei
MICROBIOLOGY
- Facultative, aerobic, nonmotile, slender, intracellular, Gram-negative rod thrives intracellularly by modulating host immune-signaling pathways.[3][6]
- B. mallei is the agent of glanders, a disease of solipeds: horses, donkeys, and mules.[18]
- If suspected, notify lab personnel
- B. mallei is highly infectious as an aerosol.
- Classified as a Tier 1 biological select agent, https://www.selectagents.gov, accessed 6/3/23.
- The Federal Select Agent Program lists excluded attenuated strains with potential for vaccine development.
- Sometimes erroneously identified as Pseudomonas sp. by standard microbiologic testing, B. mallei is morphologically indistinguishable from B. pseudomallei.
- Hard to see on Gram stain. It grows slowly, best with glycerol [Fig 1].
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Last updated: July 16, 2023
Citation
Spacek, Lisa A. "Burkholderia Mallei." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540070/all/Burkholderia_mallei.
Spacek LA. Burkholderia mallei. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540070/all/Burkholderia_mallei. Accessed November 7, 2024.
Spacek, L. A. (2023). Burkholderia mallei. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540070/all/Burkholderia_mallei
Spacek LA. Burkholderia Mallei [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2024 November 07]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540070/all/Burkholderia_mallei.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Burkholderia mallei
ID - 540070
A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2023/07/16/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540070/all/Burkholderia_mallei
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -