Johns Hopkins ABX Guide
Ampicillin
INDICATIONS
FDA
FDA
- Streptococcal infections (Group A streptococcal pharyngitis, Group B Streptococci)
- Otitis media (Haemophilus influenzae, beta-lactamase negative strains)
- Diverticulitis (in combination with metronidazole)
- Gonorrhea (in combination with probenecid, however currently not recommended due to high failure rate)
- Enteric infections (Proteus mirabilisinfections, salmonellosis, shigellosis)
- Urinary tract infections
- Note: ampicillin is not recommended to be used for empirically for the treatment of cystitis by IDSA guidelines due to its poor efficacy and the very high prevalence of antimicrobial resistance among Gram-negative organisms[11].
- Bacterial vaginosis
- Endocarditis
- Meningitis
- Respiratory tract infections
- Septicemia
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Bacterial meningitis, acute, community-acquired (Listeria monocytogenes)
- Intra-abdominal abscess (in combination with gentamicin and metronidazole)
- Enterococcal endocarditis (in combination with gentamicin or ceftriaxone)
- Enterococcus infections
- Alternative therapy for enteric infections caused by Salmonella and Shigella
- Endocarditis prophylaxis
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Last updated: August 9, 2019
Citation
Avdic, Edina. "Ampicillin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540023/all/Ampicillin.
Avdic E. Ampicillin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540023/all/Ampicillin. Accessed July 18, 2025.
Avdic, E. (2019). Ampicillin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540023/all/Ampicillin
Avdic E. Ampicillin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2025 July 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540023/all/Ampicillin.
* Article titles in AMA citation format should be in sentence-case
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Y1 - 2019/08/09/
BT - Johns Hopkins ABX Guide
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PB - The Johns Hopkins University
DB - Pediatrics Central
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