Type your tag names separated by a space and hit enter

trimebutine

General

Canada-Approved Medicine

This monograph describes a medication approved for use in Canada by the Therapeutic Products Directorate, a division of Health Canada’s Health Products and Food Branch. The medication is not approved by the United States Food and Drug Administration; however, a similar formulation carrying a different generic or brand name might be available in the US.

Pronunciation:
try-meh-boo-teen

Trade Name(s)

  • Modulon Canadian Tradename

Ther. Class.
lower gastrointestinal tract motility regulators
spasmolytics

Indications

  • Symptomatic treatment of irritable bowel syndrome (IBS).
  • Treatment of postoperative paralytic ileus.

Action

Acts as a spasmolytic.

Therapeutic Effect(s):

  • ↓ symptoms of IBS.
  • Resumption of intestinal transit following abdominal surgical procedures.

Pharmacokinetics

Absorption: Rapidly absorbed following oral administration.

Distribution: Unknown.

Metabolism and Excretion: Extensively metabolized, <2.4% excreted unchanged in urine.

Half-life: 2.7–3.1 hr.

TIME/ACTION PROFILE (symptom relief)

ROUTEONSETPEAKDURATION
POwithin 3 days–2 wk1 hr (blood level)>1 wk (following discontuation)

Contraindication/Precautions

Contraindicated in:

  • Hypersensitivity.

Use Cautiously in:

  • OB: Not recommended for use;
  • Pedi: Children <12 yr (safety and effectiveness not established).

Adverse Reactions/Side Effects

CNS: dizziness, drowsiness, fatigue, headache

GI: diarrhea, dry mouth, dysguesia, dyspepsia, epigastric pain, nausea

Derm: hot/cold sensation, rash

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Drug-Drug

None known

Route/Dosage

PO: (Adults) 200 mg 3 times daily.

Availability

Tablets: 100 mg, 200 mg

Assessment

  • Assess for symptoms of irritable bowel syndrome (cramping, constipation and diarrhea, mucus in stools).
  • Assess for abdominal distention and assess bowel sounds.
  • Monitor intake and output and record.

Potential Diagnoses

  • Acute pain
  • Diarrhea

Implementation

  • PO: Administer three times daily before meals.

Patient/Family Teaching

  • Instruct patient to take trimebutine as directed.
  • Advise female patient to inform health care professional if pregnancy is planned or suspected or if breast feeding.

Evaluation/Desired Outcomes

Decrease signs and symptoms of irritable bowel disease.

trimebutine is a sample topic from the Davis's Drug Guide.

To view other topics, please or purchase a subscription.

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Learn more.

Citation

Quiring, Courtney, et al. "Trimebutine." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/109872/all/trimebutine.
Quiring C, Sanoski CA, Vallerand AH. Trimebutine. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/109872/all/trimebutine. Accessed April 26, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Trimebutine. In Davis's Drug Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/109872/all/trimebutine
Quiring C, Sanoski CA, Vallerand AH. Trimebutine [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 April 26]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/109872/all/trimebutine.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - trimebutine ID - 109872 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/109872/all/trimebutine PB - F.A. Davis Company ET - 16 DB - Pediatrics Central DP - Unbound Medicine ER -