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Avascular (Aseptic) Necrosis of the Femoral Head (Hip)

Avascular (Aseptic) Necrosis of the Femoral Head (Hip) is a topic covered in the 5-Minute Pediatric Consult.

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Basics

Description

  • Avascular (aseptic) necrosis results from the interruption of the blood supply to bone (either traumatic or nontraumatic occlusion).
  • The femoral head is the most common site.
  • A self-limiting idiopathic avascular necrosis of the hip that occurs in children is known as Perthes disease (see “Perthes Disease” chapter).

Risk Factors

Genetics

  • Variable, depending on cause
  • Steroid-induced avascular necrosis may have an underlying genetic predisposition.

Pathophysiology

  • Death and necrosis of bone with gradual return of blood supply
  • Necrotic bone gradually resorbed and replaced by new bone
  • During bone resorption, structural integrity of femoral head may be reduced, leading to collapse.

Etiology

  • Traumatic
    • Slipped capital femoral epiphysis
    • Hip fracture
    • Hip dislocation
    • Complication of casting, bracing, surgery
  • Nontraumatic
    • Steroids or chemotherapy
    • Malignancy (leukemia)
    • Idiopathic (older, after physeal closure); similar to adult avascular necrosis
    • Idiopathic (younger, before physeal closure, Perthes disease)
    • Caisson disease
    • Sickle cell disease
    • Septic arthritis
    • Gaucher disease
    • Viral infection (HIV, CMV)
    • Radiation therapy
    • Hypercoagulable states

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Citation

Cabana, Michael D., editor. "Avascular (Aseptic) Necrosis of the Femoral Head (Hip)." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617704/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_.
Avascular (Aseptic) Necrosis of the Femoral Head (Hip). In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617704/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_. Accessed April 25, 2019.
Avascular (Aseptic) Necrosis of the Femoral Head (Hip). (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617704/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_
Avascular (Aseptic) Necrosis of the Femoral Head (Hip) [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617704/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Avascular (Aseptic) Necrosis of the Femoral Head (Hip) ID - 617704 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617704/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_ PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -