Sulfadiazine

FDA

• CNS and ocular toxoplasmosis (in combination with pyrimethamine)
• Nocardia
• Malaria due to chloroquine-resistant P. falciparum (in combination with quinine and pyrimethamine)
• UTI (also FDA indicated for pyelonephritis, but generally reserved for uncomplicated UTI, trimethoprim/sulfamethoxazole [TMP/SMX] preferred)
• FDA indicated, but not generally recommended: chancroid, trachoma, inclusion conjunctivitis
• FDA indicated, but not generally recommended: prophylaxis of meningococcal meningitis when sulfonamide-sensitive group A strains are known to prevail, meningococcal meningitis, acute otitis media due to Haemophilus influenzae (in combination with PCN), prophylaxis against recurrences of rheumatic fever (alternative to penicillin), H. influenzae meningitis (in combination with streptomycin)