Streptococcal Toxic Shock Syndrome

Paul G. Auwaerter, M.D., Joel N. Blankson, M.D., Ph.D.

PATHOGENS

Streptococcus pyogenes (Group A, GAS)
- S. pyogenes produces exotoxins SPEA, SPEB, and SPEC.
  - These toxins are superantigens capable of activating up to 25% of T cells. Aspects of therapy are selected to stop toxin production.
  - Exotoxins precipitate a cytokine storm that can lead to profound hypotension and multiorgan failure.
Other Streptococcus species (described)

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