is a topic covered in the Johns Hopkins ABX Guide
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- Polymicrobial in up to 25% including anaerobes.
- Given that most splenic abscesses are secondary to bacteremia or fungemia (e.g., associated with endocarditis, UTI, pancreatitis, GI tract, etc.), the likely pathogen(s) are determined by original focus.
- Gram-negative bacilli, especially
- Staphylococcus aureus
- Candida spp.
- Neutropenia and chronic corticosteroid use predispose to candidal splenic abscesses.
- Chronic disseminated candidiasis (formerly hepatosplenic candidiasis) often include frank candidal splenic abscesses.
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